Ipamorelin: The “Clean” Tool for Growth Hormone Research

Researchers have a name for unwanted effects of a drug or peptide: "off-target." Older peptides like GHRP-6 stimulate growth hormone release, sure — but they also bump cortisol, prolactin, and appetite. Ipamorelin was built to be cleaner.

What it is

Ipamorelin is a five-amino-acid peptide developed in the 1990s. It mimics ghrelin — the hormone famous for making you hungry — but only on a specific receptor that controls growth hormone release. It mostly leaves the appetite, stress, and prolactin signals alone.

What labs have observed

In animal studies and small human trials, Ipamorelin produced strong, brief pulses of growth hormone release that closely resembled the body's natural pattern. Researchers have used it to study GH pulse biology, age-related GH decline, and recovery models.

One thing labs noticed: Ipamorelin's effects fade with continued use, suggesting the receptor it targets becomes less responsive over time. That kind of "desensitization" is itself an interesting research subject.

Why it's a researcher's favorite

If you want to ask, "what does an isolated growth hormone pulse actually do?" — Ipamorelin is one of the cleanest tools available. It changes one variable at a time, which is exactly what good experimental design demands.

Important: Ipamorelin is sold for laboratory and research use only. It is not approved for human consumption or treatment.