MOTS-c: The Peptide That Showed Mitochondria Can Talk Back

For most of the 20th century, the textbook story was simple: your nuclear DNA holds the genes, and your mitochondria are little energy factories that follow orders. Then in 2015, researchers at USC found something that changed the picture. They discovered a peptide named MOTS-c — and it was encoded inside mitochondrial DNA.

Why this was a big deal

It meant mitochondria weren't just receiving signals. They were sending them out, too. MOTS-c travels from mitochondria into the rest of the cell — and even into the bloodstream — where it appears to influence metabolism, insulin sensitivity, and how cells respond to stress.

What labs are studying

Most MOTS-c research focuses on metabolism. In animal studies, it appears to activate AMPK — an enzyme nicknamed the body's "metabolic master switch." When AMPK turns on, cells start burning fuel more efficiently, which is exactly what happens during exercise or fasting.

Other work looks at MOTS-c levels in aging humans (they tend to drop) and in conditions like type 2 diabetes and obesity.

Why it's exciting

MOTS-c is a window into a kind of cellular communication scientists didn't even know existed a decade ago. Every year, more peptides like it are being discovered hiding inside the mitochondrial genome.

Important: MOTS-c is provided for laboratory and research use only. Not approved for human consumption.