Research Use Only

Verified Research-Grade Peptides

Independent third-party COAs. Cold-chain shipping. Built for the bench.

Thymosin Beta 4 (TB500)

Price range: $34.95 through $59.95

SKU: YPB.214 Categories: ,

Description

TB500 A single-component research material supplied for controlled research environments. Suitable for studies involving peptide characterization and method development in model systems.


Composition

• Thymosin Beta 4 (TB500)
Appearance:

Documentation & Quality Assurance

Each lot is sourced through our verified global supply chain with emphasis on traceability and quality control.These documents are reviewed internally and displayed as they become available. Independent third-party testing is also performed on select lots to confirm identity, purity, and alignment with our internal specifications.


Important Notice

This product is intended for laboratory research use only. It is not intended for human or veterinary use, and must not be used for diagnostic, therapeutic, or clinical purposes.
This material is not a drug, medical device, or dietary supplement, and has not been evaluated by the U.S. Food and Drug Administration.


Quality & Manufacturing

All materials are sourced from carefully vetted domestic and international manufacturing partners who follow quality systems consistent with ISO and cGMP principles. Each supplier is reviewed for reliability, documentation integrity, and transparency in testing.

We require a verified purity of 99% or higher and perform independent third-party spot testing to confirm that select lots meet our internal standards for identity, purity, and composition. Where available, endotoxin testing results are included on Certificates of Analysis to verify laboratory purity; their inclusion is for research quality assessment only and does not imply suitability for human or veterinary use.

All research materials are sealed for integrity and packaged for stability during storage and transport from manufacturing through final delivery.

Additional information

Weight 0.0625 lbs
Dosage

5mg, 10mg

Certificate of Analysis

Every batch undergoes independent third-party laboratory analysis to verify identity, potency, and safety. Testing includes quantitative assay verification, heavy metals screening, and comprehensive microbial analysis.

Select a product option above to view its Certificate of Analysis.
Testing Protocol
Third-Party Lab Verified Quantitative Assay Heavy Metals Screened
Sterility Testing (TAMC) Yeast & Mold Testing (TYMC)

Testing performed per USP compendial standards by independent analytical laboratory

Storage Instructions

All products from Research Vials are manufactured using a lyophilization (freeze-drying) process. This method is designed to maintain product integrity and allows vials to remain stable during shipping for approximately 3–4 months.

Once a vial is reconstituted with bacteriostatic water, it should be stored in the refrigerator to help maintain stability. Under these conditions, reconstituted material is generally considered stable for up to 30 days.

Lyophilization is a dehydration technique in which compounds are frozen and then exposed to low pressure. This causes the water in the vial to sublimate directly from solid to gas, leaving behind a stable, crystalline white structure. This powder can be kept at room temperature until reconstitution.

Upon receipt, products should be stored away from heat and light. For short-term use, refrigeration at approximately 4°C (39°F) is suitable. For long-term storage (several months to years), vials may be placed in a freezer at approximately -80°C (-112°F). Freezing is the preferred method for preserving product stability over extended periods.

⚠️ Important Notice:
These products are intended for research use only. Not for human consumption.

Research Use Only

These studies reference research-grade peptides for laboratory and scientific investigation only. Not for human consumption. Not intended to diagnose, treat, cure, or prevent any disease.

Published Scientific Research

Peer-reviewed laboratory research investigating regenerative peptides from leading scientific databases

Mechanism Study
PubMed

Injectable Thymosin β4-Modified Hyaluronic Acid Hydrogel with Exosomes for Stem Cell Homing and Neuronic-Angiogenic-Osteogenic Coupled Cranial Repair.

ACS nano 2025

results demonstrated that the Exo@Tβ4/HAMA hydrogel exhibited improved mechanical properties, favorable biocompatibility, and the ability to significantly recruit BMSCs. Additionally, it showed superior vasculogenic effects on HUVECs and osteogenic differentiation potentials on BMSCs.

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In Vitro Study
PubMed

Plasmacytoid dendritic cells alleviate allergic asthma via airway epithelial cell-dependent thymosin β4 expression.

The Journal of allergy and clinical immunology 2025

METHODS: Blood dendritic cell antigen 2-diphtheria toxin receptor (BDCA2-DTR) mice were used for pDC depletion. RNA sequencing of sorted mouse lung pDCs, in vitro cell experiments, and in vivo CCR2 blockade or thymosin β4 (Tβ4) supplementation were performed to elucidate the underlying mechanism.

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Molecular Analysis
PubMed

Thymosin β4 and Actin: Binding Modes, Biological Functions and Clinical Applications.

Current protein & peptide science 2023

Based on this, Tβ4 is known to have a wide range of effects, including regulation of inflammation and tumor metastasis, promotion of angiogenesis, wound healing, regeneration of hair follicles, promotion of the development of the nervous system, and improving bone formation and tooth growth.

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Molecular Analysis
PubMed

[Research advances on thymosin β4 in promoting wound healing].

Zhonghua shao shang yu chuang mian xiu fu za zhi 2022

With the aging of population and the development of social economy, the incidence of chronic wounds is increasing day by day, while the incidence of burns and trauma remains at a high level, making wound repair an increasingly concerned area in clinical practice. Thymosin β4 is a naturally occurring small molecule protein in vivo, which is widely distributed in a variety of body fluids and cells, especially in platelets. Thymosin β4 has biological activities of promoting angiogenesis, anti-inf

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Molecular Analysis
PubMed

Thymosin β4 Is an Endogenous Iron Chelator and Molecular Switcher of Ferroptosis.

International journal of molecular sciences 2022

However, the precise roles and mechanism(s) of action of Tβ4 in these processes remain largely unknown, with the binding of the G-actin protein being insufficient to explain these multi-actions. Here we identify for the first time the important role of Tβ4 mechanism in ferroptosis, an iron-dependent form of cell death, which leads to neurodegeneration and somehow protects cancer cells against cell death.

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Molecular Analysis
PubMed

Multiple potential roles of thymosin β4 in the growth and development of hair follicles.

Journal of cellular and molecular medicine 2021

However, the molecular mechanisms through which Tβ4 promotes HF growth and development have rarely been reported. Herein, we review the functions and mechanisms of Tβ4 in HF growth and development and describe the endogenous and exogenous actions of Tβ4 in HFs to provide insights into the roles of Tβ4 in HF growth and development.

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Frequently Asked Questions

Essential information about our research-grade peptides and quality standards.

Peptides are short chains of amino acids linked by peptide bonds, typically consisting of 2-50 amino acids. They serve as the building blocks of proteins and play crucial roles in biological processes.

Research peptides are synthesized versions of naturally occurring peptides, manufactured to precise specifications for use in scientific studies.

Key characteristics: High purity (≥98%), lyophilized form for stability, accompanied by Certificates of Analysis (COA), and manufactured under strict quality control protocols.

Peptide purity refers to the percentage of the target peptide present in a sample, measured via High-Performance Liquid Chromatography (HPLC).

Our Standard: All our research peptides maintain ≥98% purity, verified by third-party laboratory testing and documented in our Certificates of Analysis.

Higher purity is critical for research because impurities can interfere with experimental results and compromise the reproducibility of studies.

All products are supplied in lyophilized powder form within sterile, sealed vials. This format provides:

  • Maximum stability: Extended shelf life compared to liquid solutions
  • Precise measurement: Researchers can work with desired quantities
  • Contamination protection: Sealed vials prevent environmental exposure
  • Shipping durability: Powder form is more stable during transit

Lyophilized peptides:

  • Store at -4°F for long-term storage (up to 24 months)
  • Store at 36-46°F (refrigerated) for short-term storage (up to 3 months)
  • Keep away from light, moisture, and repeated temperature fluctuations

We supply research-grade peptides to:

  • Academic and university research laboratories
  • Pharmaceutical and biotechnology companies
  • Independent research institutions
  • Licensed professionals conducting legitimate scientific research

We maintain rigorous quality control through a multi-step verification process:

  • HPLC Analysis: Every batch tested to verify ≥98% purity
  • Mass Spectrometry: Molecular weight confirmation for peptide identity
  • Third-Party Testing: Independent laboratory verification
  • Sterility Protocols: Aseptic handling and packaging procedures
  • Batch Documentation: Complete traceability from synthesis to delivery

"Research Use Only" (RUO) is a classification indicating that a product is intended exclusively for laboratory research and experimental investigation.

All orders are shipped with research-grade handling protocols:

  • Packaging: Insulated containers with cold packs when required
  • Carriers: USPS Priority Mail
  • Processing: Orders placed before 12 PM EST ship same business day
  • Tracking: Full tracking information provided via email

We stand behind every product:

  • Quality guarantee: Full replacement or refund if products don't meet stated specifications
  • Shipping issues: Free replacement for damaged or lost shipments
  • Unopened returns: Accepted within 30 days for store credit
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⚠️ Research Use Only — Legal Acknowledgment

All products on this website are sold strictly for in vitro research and laboratory use only.

  • Not for human or veterinary use, consumption, or application
  • Not FDA-approved to diagnose, treat, cure, or prevent any disease
  • Buyer assumes full responsibility for legal compliance in their jurisdiction

This information is collected for merchant compliance and regulatory purposes.

Please select your research affiliation to continue.

By clicking "Accept," you confirm:

  • You are at least 21 years of age
  • You are a qualified researcher or laboratory professional
  • You represent the affiliation type selected above
  • You understand these products are for research purposes only
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